PHP 5.3.3 or a newer version of PHP.
PECL/mysqlnd_qc is a mysqlnd plugin. It plugs into the mysqlnd library. To use you this plugin with a PHP MySQL extension, the extension (mysqli, mysql, or PDO_MYSQL) must enable the mysqlnd library.
For using the APC storage handler with PECL/mysqlnd_qc 1.0 APC 3.1.3p1-beta or newer. PECL/mysqlnd_qc 1.2 has been tested with APC 3.1.13-beta. The APC storage handler cannot be used with a shared build. You cannot use the PHP configuration directive extension to load the APC and PECL/mysqlnd_qc extensions if PECL/mysqlnd_qc will use APC as a storage handler. For using the APC storage handler, you have to statically compile PHP with APC and PECL/mysqlnd_qc support into PHP.
For using MEMCACHE storage handler: Use libmemcache 0.38 or newer. PECL/mysqlnd_qc 1.2 has been tested with libmemcache 1.4.0.
For using sqlite storage handler: Use the sqlite3 extension that bundled with PHP.